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143b human osteosarcoma cell line  (ATCC)


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    ATCC 143b human osteosarcoma cell line
    143b Human Osteosarcoma Cell Line, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1601 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/143b human osteosarcoma cell line/product/ATCC
    Average 99 stars, based on 1601 article reviews
    143b human osteosarcoma cell line - by Bioz Stars, 2026-02
    99/100 stars

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    Clinical characteristics and prognostic factor PEA15 in the OS autophagy-related model (A) Kaplan-Meier survival analysis of the OS prognostic factor PEA15. (B) Risk survival status plot. (C and D) Univariate and multivariate COX regression analyses of the OS autophagy-related model and various clinical features. (E) mRNA expression levels of PEA15 in the normal osteoblast cell line hFOB1.19 and four <t>osteosarcoma</t> cell lines. (F and G) Validation of knockdown efficiency in <t>U2OS</t> cells and overexpression efficiency in <t>MG63</t> cells ( n = 3). (H and I) CCK-8 assays of cell proliferation following PEA15 knockdown and overexpression ( n = 3). (J–M) Validation of autophagy activity in human tumor tissues and corresponding statistical analysis ( n = 3). (N and O) Protein expression levels of PEA15 are validated by knockdown and overexpression experiments. The data are presented as mean ± SD. ∗∗ p < 0.01, ∗∗∗ p < 0.001. n.s.: not significant.
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    Clinical characteristics and prognostic factor PEA15 in the OS autophagy-related model (A) Kaplan-Meier survival analysis of the OS prognostic factor PEA15. (B) Risk survival status plot. (C and D) Univariate and multivariate COX regression analyses of the OS autophagy-related model and various clinical features. (E) mRNA expression levels of PEA15 in the normal osteoblast cell line hFOB1.19 and four osteosarcoma cell lines. (F and G) Validation of knockdown efficiency in U2OS cells and overexpression efficiency in MG63 cells ( n = 3). (H and I) CCK-8 assays of cell proliferation following PEA15 knockdown and overexpression ( n = 3). (J–M) Validation of autophagy activity in human tumor tissues and corresponding statistical analysis ( n = 3). (N and O) Protein expression levels of PEA15 are validated by knockdown and overexpression experiments. The data are presented as mean ± SD. ∗∗ p < 0.01, ∗∗∗ p < 0.001. n.s.: not significant.

    Journal: iScience

    Article Title: PEA15 promotes osteosarcoma progression and cisplatin resistance by modulating autophagy through the FABP3-TNF signaling axis

    doi: 10.1016/j.isci.2025.113695

    Figure Lengend Snippet: Clinical characteristics and prognostic factor PEA15 in the OS autophagy-related model (A) Kaplan-Meier survival analysis of the OS prognostic factor PEA15. (B) Risk survival status plot. (C and D) Univariate and multivariate COX regression analyses of the OS autophagy-related model and various clinical features. (E) mRNA expression levels of PEA15 in the normal osteoblast cell line hFOB1.19 and four osteosarcoma cell lines. (F and G) Validation of knockdown efficiency in U2OS cells and overexpression efficiency in MG63 cells ( n = 3). (H and I) CCK-8 assays of cell proliferation following PEA15 knockdown and overexpression ( n = 3). (J–M) Validation of autophagy activity in human tumor tissues and corresponding statistical analysis ( n = 3). (N and O) Protein expression levels of PEA15 are validated by knockdown and overexpression experiments. The data are presented as mean ± SD. ∗∗ p < 0.01, ∗∗∗ p < 0.001. n.s.: not significant.

    Article Snippet: The human osteoblastic cell line hFOB1.19 and human osteosarcoma (OS) cell lines (U2OS, MG63, SAOS2, 143B) were obtained from the American Type Culture Collection (ATCC).

    Techniques: Expressing, Biomarker Discovery, Knockdown, Over Expression, CCK-8 Assay, Activity Assay